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Microbial regulation of human colon immune homeostasis
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Microbial regulation of human colon immune homeostasis
Annotation
PII
S0869587325020095-1
Publication type
Article
Status
Published
Authors
O. V. Bukharin 
Occupation: Academician of the Russian Academy of Sciences, Scientific Director
Affiliation: Institute for Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
E. V. Ivanova
Occupation: Doctor of Medical Sciences, Head of the Laboratory of Infectious Symbiology
Affiliation: Institute for Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
I. N. Chaynikova
Occupation: Doctor of Medical Sciences, Leading Researcher at the Laboratory of Infectious Symbiology
Affiliation: Institute for Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences
Edition
Volume 95 Issue number 2
Pages
85-93
Abstract
The article presents a fresh look at the role of the intestinal microbiota in symbiosis with the human body. The study of the “microbe–host” system in the framework of infectious symbiology allowed us to establish that intestinal bacteria regulate and maintain the immune homeostasis of the large intestine with the help of their metabolites. Thus, it became possible to control the immune homeostasis of the large intestine through exposure to associations of microsymbionts capable of altering the cytokine status and response of innate immunity. Multicomponent associations of microsymbionts of the large intestine have been established, which under conditions of eubiosis maintain a balanced profile of pro- and anti-inflammatory cytokines. In dysbiosis, an increased number of associations of opportunistic pathogens leads to a shift in the balance towards pro-inflammatory cytokines and an increase in the level of antimicrobial proteins in the intestine. The multidirectional effects on cytokine production of extracellular metabolites of microsymbionts isolated during eubiosis and dysbiosis can serve as the basis for the selection of strains with anti-inflammatory activity.
Keywords
кишечная микробиота метаболиты бактерий цитокиновый профиль эффекторы врождённого иммунитета пробиотические штаммы
Received
27.04.2025
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References

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